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. 2020 Oct 15;13:10475–10487. doi: 10.2147/OTT.S253758

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© 2020 Sun et al.

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CDC20 regulated DLBCL cell proliferation, apoptosis, and cell cycle in vitro. (A and B) OCI-Ly3 and OCI-Ly10 cells were treated with Apcin (200 μM) for 48 h. The percentage of EdU-positive cells could be measured using a confocal microscope (×100; scale bar, 100 μm). (C and D) OCI-Ly3 and OCI-Ly10 cells were treated with Apcin (200 μM) and stained with Annexin V-FITC and PI, and then, the rate of apoptotic cells was analyzed by flow cytometry. (E and F) Cell cycle distribution of OCI-Ly3 and OCI-Ly10 was analyzed by using flow cytometry. **P < 0.01; ***P < 0.001; ****P < 0.0001.

Abbreviations: DLBCL, diffuse large B-cell lymphoma; EdU, 5-ethynyl-2ʹ-deoxyuridine; DAPI, 4ʹ,6-diamidino-2-phenylindole; Annexin V-FITC, annexin A5-fluorescein isothiocyanate; PI, propidium iodide.