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. 2020 Oct 15;13:10475–10487. doi: 10.2147/OTT.S253758

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© 2020 Sun et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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MDM2-p53-CDC20 signaling pathway in DLBCL cells. (A and B) OCI-Ly3 and OCI-Ly10 cells were transfected with si-MDM2, and MDM2, wtp53 and CDC20 protein expressions were detected by Western blot assay. (C and D) OCI-Ly3 and OCI-Ly10 cells were treated with RG7388, and MDM2, wtp53 and CDC20 protein expressions were identified by Western blot assay. (E and F) OCI-Ly3 and OCI-Ly10 cells were treated with Apcin, and the expression levels of MDM2, wtp53, and CDC20 were detected by Western blot assay. (G) Based on GeneMANIA (http://genemania.org/) analysis, molecular functional network of MDM2-p53-CDC20 pathway was generated.

Abbreviations: DLBCL, diffuse large B-cell lymphoma; KD, knocked down; Ctrl, control.