Figure 1.

TH signaling in the brain depends on a triad of elements that regulate TH action: (i) transmembrane transporters, ie, OATPs, MCTs, and LATs, that mediate passage of both T4 and T3 through the blood brain barrier and local cells; (ii) deiodinases metabolize TH locally, ie, DIO2 and DIO3, respectively activating and inactivating TH; (iii) TRs, mostly TRα and to a lesser extent TRβ. In the present in silico studies, microarray data previously derived from 19 human Brodmann area 38 (temporal pole) samples was used to generate a T3 positive signaling index (T3S+).