TABLE 4.
Top hub genes in mitochondria function modules (I and II)
| Module | Gene symbol | Gene name | Definition |
|---|---|---|---|
| Mitochondrial function I | ATP5O | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit | ATP synthase, H+ transporting |
| AURKAIP1 | Aurora kinase A interacting protein 1 | Ribosomal subunit protein | |
| COX14 | Cytochrome C oxidase assembly factor | Role in coordinating cytochrome C oxidase | |
| COX4I1 | Cytochrome C oxidase subunit 4I1 | Terminal enzyme of the mitochondrial respiratory chain | |
| MYEOV2 | Myeloma-overexpressed gene 2 protein | Role in cell proliferation | |
| NDUFA4 | NADH dehydrogenase (ubiquinone) 1 alpha, mitochondrial complex associated | NADH: transfers electrons from NADH to respiratory chain | |
| NDUFB8 | NADH: ubiquinone oxidoreductase subunit B8 | NADH: transfers electrons from NADH to respiratory chain | |
| NDUFV2 | NADH: ubiquinone oxidoreductase core subunit V2 | NADH: transfers electrons from NADH to respiratory chain | |
| RPL23A | Ribosomal protein L23a | Involved in mediating growth inhibition by interferon | |
| UQCR11 | Ubiquinol-cytochrome C reductase, complex III subunit XI | Forms part of mitochondrial respiratory chain: Metabolism, electron transport, ATP synthesis, heat production by uncoupling proteins | |
| Mitochondrial function II | ACO2 | Aconitase 2 | Enzyme involved in second step of TCA cycle |
| ALDH2 | Aldehyde dehydrogenase 2 family (mitochondrial) | Oxidizes aldehydes to generate carboxylic acids for use in muscle and heart | |
| ATP5B | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | Subunit of mitochondrial ATP synthase (catalyzes ATP synthesis) | |
| FH | Fumarate hydratase | Component of TCA cycle | |
| MAPKAPK3 | Mitogen-activated protein kinase-activated protein kinase 3 | Induced by growth inducers and stress stimulation of cells: involved in cytokines production, endocytosis, cell migration, chromatin remodeling, and transcriptional regulation | |
| NDUFV1 | NADH: ubiquinone oxidoreductase core subunit V1 | NADH subunit | |
| PDK2 | Pyruvate dehydrogenase kinase 2 | Regulates glucose/fatty acid metabolism through TCA cycle plays an important role in maintaining normal blood glucose levels. Plays a role in resistance to apoptosis under oxidative stress | |
| PEBP1 | Phosphatidylethanolamine binding protein 1 | Involved in modulating MAPK, NF-kappa B, GSK-3 signaling pathways | |
| SDHA | Succinate dehydrogenase complex flavoprotein subunit A | A complex of mitochondrial respiratory chain | |
| UQCRC1 | Ubiquinol-cytochrome C reductase core protein I | A part of the mitochondrial respiratory chain |
Highest ranked Hub genes within mitochondrial modules ranked by MCC score.
MCC, Maximal Clique Centrality; NADH, nicotinamide adenine dinucleotide + hydrogen.