Table 3.
Diagnostic Performance of POC TNI and Lab HTNT Assays
| POC TNI First Test (Zero Hour) |
POC TNI Second Test (After 3 Hours) |
HTNT – First Test (Zero Hour) | HTNT – Second Test (After 3 hrs) |
|
|---|---|---|---|---|
| Sensitivity (95% CI) | 72.5 (57.2–83.9) | 95 (83.5–98.6) | 97.5 (87.1–99.5) | 100 (91.2–100) |
| Specificity (95% CI) | 99.24 (97.3–99.8) | 100 (98.6–100%) | 93.2 (89.5–95.6) | 94.3 (90.8–96.5) |
| PPV (95% CI) | 93.5 (79.3–98.2) | 100 (90.8–100) | 68.4 (55.5–79) | 72.7 (59.7–82.7) |
| NPV (95% CI) | 95.96 (92.9–97.7) | 99.2 (97.3–99.8) | 99.6 (97.7–99.9) | 100 (98.5–100) |
| Diagnostic accuracy (%) | 95.7 (92.8–97.5) | 99.3 (97.6–99.8) | 93.7 (90.4–95.9 | 95 (91.9–96.9) |
| Likelihood ratio of a positive test | 95.3 (34.8–260.6) | undefined | 14.3 (12.8–15.9) | 17.53 (15.4–19.9) |
| Likelihood ratio of a negative test | 0.27(0.23–0.33) | 0.05 (0.01–0.13) | 0.02 (0.00–0.19) | 0.0 |