Prone position improves mortality in patients with acute respiratory distress syndrome (ARDS), though its role in the treatment in critically ill COVID-19 patients remains to be determined.

Prone position has been increasingly used in non-intubated patients with COVID-19, and studies show high tolerance and improvement in oxygenation and lung recruitment.

Published COVID-19 studies describing the use of prone position lacked a description of important clinical outcomes (e.g., mortality, duration of mechanical ventilation).

A trial of prone position should be considered for non-intubated COVID-19 patients with hypoxemic respiratory failure, as long as this does not result in a delay in intubation.