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. 2020 Oct 20;6:106. doi: 10.1038/s41420-020-00340-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Total number of genes differentially expressed in the hearts of neonatal HMGB1^△CM compared to their control littermates. b Volcano plots and biological process most significantly associated with the dysregulated genes in the neonatal knockout hearts as determined by DAVID. c Total number of genes differentially expressed in the hearts of 12-week-old HMGB1^△CM mice compared to their control littermates. d Volcano plots and biological process most significantly associated with the dysregulated genes in the adult knockout hearts as determined by DAVID. e The physical interaction of HMGB1 and glucocorticoid receptor was analysed by immunoprecipitation and western blot analysis. f The effect of HMGB1 knockout on the recruitment of GR onto the Fkbp5 and Klf15 promoters was assessed by ChIP assays using an anti-GR antibody and neonatal hearts. Amounts of ChIP DNA were measured with quantitative PCR. n = 6/group. g qRT-PCR results of the GR downstream genes in neonatal hearts of the two groups, n = 6/group. *p < 0.05 versus control, t-test, mean ± SEM.