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. 2020 Oct 20;10:17807. doi: 10.1038/s41598-020-74664-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prenatal mammary gland development in mice with embryonal Sox10 deletion. (a–g) X-gal staining was performed at E14.5 (a,b), E16.5 (c,d) and E18.5 (e–g) on ventral dermis including mammary gland anlagen to detect β-galactosidase activity in Sox10^+/lacZ (a,c,f), Sox10^lacZ/lacZ (b,d,g) and control Sox10::Cre Rosa26^{stopflox-lacZ} (e) mouse embryos. Staining is in the mammary gland anlagen (asterisks) and peripheral nerves (arrowheads). Magnifications in right upper corner (a–d) or on right (e–g) correspond to boxed areas in main panels. (h–v) Confocal sections of mammary gland ducts at E18.5 (h–q) and P56 (r–v) in Sox10^lacZ/lacZ (h–l) and Sox10^+/+ (m–v) mice. Immunohistochemistry was performed using antibodies directed against keratin 14 (h,m,r), keratin 8 (i,n,s), β-galactosidase (βGal, j) and Sox10 (o,t). Single (h–j,m–o,r–t) or merged (k,l,p,q,u,v) stainings are shown. Scale bars: 50 µm (b,d), 2 mm (g), 10 µm (l,q,v).