Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 20;11:5067. doi: 10.1038/s41467-020-18784-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Schematic of the pilosebaceous unit indicating the upper region, consisting of interfollicular epidermis (IFE), infundibulum (INF), junctional zone (JZ), sebaceous duct (SD), and sebaceous gland (SG), then the isthmus (IST) and the lower region of the hair follicle (HF) comprising the bulge (Bu), hair shaft (HS), inner root sheath (IRS), and outer root sheath (ORS). The lower right panel shows the structure and differentiation of the human SG. b–e Immunolabelling for GATA6 (b–e) and ITGα6 (b), IVL (c), FASN (d) and KRT7 (e), with DAPI counterstain of back skin sections from a 60 year old male. Middle and right panels in b are higher magnification views of the left panel section. Yellow asterisks show basal GATA6+ cells. Scale bar: 100 μm, except in b right panels: 25 μm. Data are representative of two independent experiments. f 2D Uniform Manifold Approximation and Projection (UMAP) visualisation of single cells isolated from healthy human scalp epidermis and adnexa²⁹ coloured by Seurat cluster. g GATA6 expression levels, as log₁₀ Transcripts Per Million (TPM), across the 24 different clusters. GATA6 is mainly expressed in cluster 22. h Differentially expressed genes (DEG) of cluster 22. Only DEG with log₂FC > 0.2 or < −0.2 are shown. i Intersection of the 250 most upregulated DEG of cluster 22 identified in scalp epidermis within cell populations identified by Cheng et al.²⁹ HR-WNTI stands for High Resolution-WNT Inhibitory cluster and UHF for upper hair follicle cluster. j GO enrichment analysis of the 250 most upregulated DEG of cluster 22.