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. 2020 Oct 20;11(10):879. doi: 10.1038/s41419-020-03101-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Gene Set Enrichment Analysis (GSEA) showed genes that are positively correlated to high IPO13 expression on the left side (red), while genes with negative correlation are shown on the right side (blue). B IHC analysis of IPO13 expression in NSCLC tumor tissues with various EGFR status (wild and mutant). Scale bar, 100 μm. C Human lung cancer cells H1975 (L858R and T790M) and H1299 (wild type) treated with different concentrations of osimertinib for 24 h; then MTT assay was used to test the viability of the cells. Data presented as mean ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001. D The expression of IPO13 protein and phosphorylation levels of EGFR in treated cells detected by immunoblot assay. E Significant pathways obtained by GSEA that strongly correlated with IPO13 expression, including apical junction, glycolysis, and DNA repair.