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. 2020 Oct 20;10:17787. doi: 10.1038/s41598-020-74246-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The heatmap analysis of altered metabolites in serum and heart tissues. (A) The heatmap analysis of the 42 metabolites in control and ISO groups and (B) the 24 puerarin-regulated metabolites in Control, ISO, Pue-L and Pue-H groups. And S represented the levels of metabolites in the serum, and H represented that in heart.