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. 2020 Oct 20;11(10):883. doi: 10.1038/s41419-020-03083-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A qRT-PCR analysis of KCNQ1OT1 expression in A549/IR and H1975/IR cells after infected with a control (sh-ctrl) or KCNQ1OT1 shRNA knockdown (sh-KCNQ1OT1) lentiviral vector. B Cell viability of KCNQ1OT1 knockdown and control A549/IR and H1975/IR via CKK8 assay. C–E Colony survival assay in KCNQ1OT1 knockdown and control A549/IR (C) and H1975/IR (D) cells exposed with indicated irradiation dosage. Representative images were presented (E). F–H The weights (F) and volumes (H) of subcutaneous xenografts from KCNQ1OT1 knockdown and control A549/IR cells in nude mice with or without IR, n = 3 in each group. Representative images of the xenografts were presented (H). G H&E staining, Ki67 expression by IHC in the xenografts derived from KCNQ1OT1 knockdown and control A549/IR cells with or without irradiation. Scale bars: 150 μm. The black arrow represents necrosis. The histograms showed the average Ki67 proliferative index of each group. Data are presented as the mean ± SD. from three independent experiments, *p < 0.05.