Table 5.

Pre-symptomatic tests in first-degree relatives of germline BRCA1/2 pathogenic variant heterozygotes since November 2017 in the North West of England.

Index cases since November 2017	No. of families	Predictive tests	Total unaffected FDR
Standard genetics referral	39	44	93 (47.3)
Mainstreaming	39	31	98 (31.6)

Data presented as number or number (percentage). There was a significantly higher uptake in those with standard genetics referral compared to those with a mainstreaming approach (P = 0.038).

FDR first-degree relative.