Table 1.
The parameters used for matrix-assisted pulsed laser evaporation of amphotericin B onto the surfaces of the polyglycolic acid microneedles. AmfB(260) indicates deposition using a target containing amphotericin B 1040 mg/mL + 1% polyvinylpyrrolidone and AmfB(520) indicates deposition using a target containing amphotericin B 2080 mg/mL + 1% polyvinylpyrrolidone.
| Target | T | C (Hz) | Pressure (mbar) | Spot size (mm2) | Fluence (mJ/cm2) | Number of pulses | Distance (cm) |
|---|---|---|---|---|---|---|---|
| AmfB(260) | RT | 10 | 1.6 x 10-2 | 30 | 300 | 150000 | 5 |
| AmfB(520) | RT | 10 | 1.6 x 10-2 | 30 | 300 | 150000 | 5 |