Table 1.

List of stress-related proteins discussed in this review.

Biological process		Protein	Gene locus	Metal ions in structure	Assembly	PDB code (resolution)	Reference	Comments
DNA repair	DSB end resection	RecJ	DR_1126	Mn2+	monomer	5F54, 5F55, 5F56 (2.3–2.7 Å)	[15]	5′−3′ ssDNA-specific exonuclease
		RecQ	DR_1289	Zn2+	monomer	2RHF, 4Q48, 4Q47 (2.8–2.9Å)	[38], [39], [40]	ATP-dependent 3ʹ-5ʹ helicase
		UvrD	DR_1775	Mg2+	monomer	4C2T, 4C2U, 4C30 (2.6–4.0Å)	[41]	ATP-dependent bidirectional helicase
	DNA end protection	DdrA	DR_0423	–	large oligomer	Negative stain electron microscopy	[45]	ssDNA-binding protein
	Single-strand annealing	DdrB	DR_0070	–	pentamer	4HQB, 4NOE (2.2–2.3 Å)	[49], [50]	single-strand annealing activity
	Activation of DNA ligase and DNA gyrase	PprA	DR_A0346	–	filament	6A27, 6A28, 6A29 (1.3–2.4Å)	[55]	preventing nuclease-mediated degradation
	DNA damage response	PprI	DR_0167	Zn2+	dimer	3DTK, 3DTE, 3DTI (2.6–3.5Å)	[57]	metalloprotease
	Recombinational repair	DdrO	DR_2574		dimer	6JQ1, 6RMQ, 6RNX (2.3–3.0Å)	[19], [20]	transcriptional repressor
	Base excision repair	PolX	DR_0467	Zn2+	monomer	2W9M (2.5Å)	[79]	X family DNA polymerase
	Recombinational repair	RecO	DR_0819	Zn2+	monomer	1W3S, 1U5K, 2V1C (2.0–3.8Å)	[74], [75], [77]	promoting RecA loading on SSB-coated ssDNA
		RecR	DR_0198	Zn2+	tetramer	1VDD, 2V1C (2.5–3.8Å)	[76], [77]	DNA binding and form complex with RecO
Antioxidation	Oxidoreductase	KatE1	DR_1998		tetramer	4CAB (2.6Å)	[58]	clade 1 type of monofunctional catalase
		MnSOD	DR_1279	Mn2+	dimer	2CDY, 2CE4, 2AW9 (2.0–2.7Å)	[59]	Mn-containing SOD
		TrxR	DR_1982	–	dimer	2Q7V (1.9Å)	[27]	thioredoxin reductase involved in ROS scavenging
		FrnE	DR_0659	–	dimer	5CNW 5CO3, 5COH, 5E59 (1.6–2.0Å)	[60]	cytoplasmic disulfide oxidoreductase
	Metal ion homeostasis	Dps1	DR_2263	Zn2+	dodecameric	2F7N, 2C2U, 2C2F (1.1–2.0Å)	[65], [66]	ferritin family protein involved in ROS detoxification, DNA protection and iron uptake and storage.
		Dps2	DR_B0092	Fe3+	dodecameric	2C2J, 2C6R (2.1Å)	[67]
	Mn transporter	MntH	DR_1709	Mn2+	monomer	6D91, 6C3I, 6BU5, 6D9W (2.4–4.0Å)	[69]	manganese transporters belonging to bacterial Nramp family protein
Quorum sensing		LuxS	DR2387	Zn2+	dimer	1INN, 1VJE (1.6–1.8Å)	[80]	protein involved in quorum sensing
Stress-response		DinB	DR_0053	Zn2+	dimer	6IZ2 (2.1Å)	[78]	DinB/YfiT family protein