Table 5A.
Model-adjusted means* (SEM) and corresponding P-values for health-related outcomes and ADG from Day 0 to Day 60 by treatment group for steers with a WS = 1.
| Parameter | Salinea | FTSa | TILa | TIL + FTSa | P-value FTSα | P-value TILβ | P-value TIL + FTSδ |
|---|---|---|---|---|---|---|---|
| Incoming body weight (lbs) | 663.7 (5.5) | 660.0 (4.0) | 663.4 (4.0) | 660.8 (4.0) | 0.48 | 0.95 | 0.90 |
| BRD retreatment (%) | 15.0 (2.8) | 18.5 (2.2) | 10.4 (1.7) | 8.2 (1.5) | 0.95 | <0.01 | 0.17 |
| Day on Feed (DOF) at BRD retreatment (%) | 21.6 (3.6) | 23.1 (2.7) | 31.6 (3.3) | 34.1 (3.3) | 0.32 | <0.01 | 0.80 |
| BRD 3rd treatment (%) | 7.4 (2.1) | 9.9 (1.7) | 3.4 (1.0) | 3.2 (1.0) | 0.68 | <0.01 | 0.48 |
| BRD case-fatality (%) | 0.57 (0.6) | 1.2 (0.6) | 0.49 (0.4) | 0.85 (0.5) | 0.39 | 0.76 | 0.91 |
| Removals (%) | 2.4 (1.2) | 5.0 (1.2) | 1.8 (0.7) | 1.2 (0.5) | 0.67 | 0.04 | 0.17 |
| DNF (%)b | 2.9 (1.3) | 5.8 (1.3) | 2.3 (0.8) | 2.0 (0.8) | 0.41 | 0.07 | 0.26 |
| ADG (lbs/day)c | 3.2 (0.1) | 3.0 (0.1) | 3.5 (0.1) | 3.6 (0.1) | 0.59 | <0.01 | 0.06 |
Mixed models with a random effect to account for lack of independence among treatment groups within pens, and pens within 2 different sites. Mean and SEM listed above reflect the interactive means of the model.
Saline, negative control; FTS, Flunixin transdermal solution; TIL, tildipirosin; and TIL + FTS, concurrent administration of TIL and FTS.
DNF, did not finish; a combination of both calves that died or were removed due to BRD from Day 0 to 60 of this study.
ADG, Average Daily Gain.
P-values reflect the overall effect of FTS, TIL, and their interaction, respectively. P-values for each main effect reflect a model-adjusted average between treatments incorporating the product compared to those that do not. For example, the P-value for the FTS main effect reflects the comparison between treatments that implement FTS (i.e., FTS and TIL + FTS) vs. those that do not (i.e., Saline + TIL). Only when the P-value for the interaction is significant (P ≤ 0.05) are direct comparison made between the four treatment groups.
P-value for main effect of Flunixin transdermal solution.
P-value for main effect of tildipirosin.
P-value for interaction of tildipirosin and Flunixin transdermal solution.