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. 2020 Oct 7;7:571697. doi: 10.3389/fvets.2020.571697

Table 6B.

Model-adjusted means* (SEM) and corresponding P-values for health-related outcomes and ADG from Day 0 to closeout by treatment group for steers with a WS > 2.

Parameter Salinea FTSa TILa TIL + FTSa P-value FTSα P-value TILβ P-value TIL + FTSδ
BRD case-fatality (%) 3.1 (1.4) 3.4 (1.0) 3.3 (1.0) 1.5 (0.7) 0.54 0.50 0.44
Removals (%) 5.3 (1.8) 6.3 (1.4) 1.8 (0.7) 2.1 (0.8) 0.66 <0.01 0.95
DNF (%)b 8.8 (2.1) 9.4 (1.6) 5.0 (1.2) 3.5 (1.0) 0.68 <0.01 0.31
Adjusted-ADG (lbs/day)c 3.3 (0.05) 3.3 (0.03) 3.3 (0.03) 3.3 (0.03) 0.94 0.11 0.79
*

Mixed models with a random effect to account for lack of independence among treatment groups within pens, and pens within 2 different sites.

a

Saline, negative control; FTS, Flunixin transdermal solution; TIL, tildipirosin; and TIL + FTS, concurrent administration of TIL and FTS.

b

DNF, did not finish; a combination of both calves that died or were removed due to BRD from Day 0-closeout of this study.

c

Adjusted-ADG: adjusted Average Daily Gain based on a 63% carcass yield.

**

P-values reflect the overall effect of FTS, TIL, and their interaction, respectively. P-values for each main effect reflect a model-adjusted average between treatments incorporating the product compared to those that do not. For example, the P-value for the FTS main effect reflects the comparison between treatments that implement FTS (i.e., FTS and TIL+FTS) vs. those that do not (i.e., Saline + TIL). Only when the P-value for the interaction is significant (P ≤ 0.05) are direct comparison made between the four treatment groups.

α

P-value for main effect of Flunixin transdermal solution.

β

P-value for main effect of tildipirosin.

δ

P-value for interaction of tildipirosin and Flunixin transdermal solution.