Table 1.
List of known DAMPs in UUO.
| DAMPs | Putative Receptors | Pro-fibrotic | References |
|---|---|---|---|
| Biglycan | TLR2, TLR4, NLRP3 | N/A | (10) |
| Decorin | TLR2, TLR4 | ⚬ | (11, 12) |
| HMGB1 | TLR2, TLR4, TLR9, RAGE | ⦁ | (13–15) |
| IL-1α | IL-1R | N/A | (16, 17) |
| IL-33 | ST2 | ⦁ | (18, 19) |
| Necrotic DNA | TLR9, ALR | ⦁ | (20, 21) |
| sUa | NLRP3 | ⦁ | (22) |
| S100A8/A9 | TLR2, TLR4, RAGE | ⦁ | (23, 24) |
| Uromodulin | TLR4 | ⚬ | (25) |
Black dot indicates that the criterion is fulfilled; white dot indicates that the criterion is not fulfilled; N/A, no data available for the UUO model. TLR, toll-like receptor; RAGE, receptor for advanced glycation end-products; NLRP3, NOD-, LRR-, and pyrin domains-containing protein 3; HMGB1, high mobility group box 1; ALR, absent in melanoma 2-like receptors; sUa, soluble uric acid.