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. 2020 Oct 7;11:581300. doi: 10.3389/fimmu.2020.581300

Table 2.

Open questions.

Do mitochondrial DAMPs contribute to renal fibrosis?
Do other inflammasomes, beside NLRP3 and AIM2, play a role in sterile inflammation and fibrosis after UUO?
Can DAMPs be used as suitable markers for renal fibrosis and the severity of UUO?
Are the results of DAMP inhibition seen in mice reproducible in patients?