Table 2.
Open questions.
| Do mitochondrial DAMPs contribute to renal fibrosis? |
| Do other inflammasomes, beside NLRP3 and AIM2, play a role in sterile inflammation and fibrosis after UUO? |
| Can DAMPs be used as suitable markers for renal fibrosis and the severity of UUO? |
| Are the results of DAMP inhibition seen in mice reproducible in patients? |