TABLE 4.

Drug resistance and metabolism.

Molecules/drugs	Status	Major effects	Pathway	Tumor types	Type of Immune cells	References
LSD1	Up	Decreases TNBC tolerance to chemotherapy drugs	LSD1 inhibitor combined with PD-1 antibody can significantly increase CD8 + T cell infiltration	TNBC	CD8 + T cells	(62)
CCL20	Up	Promote self-renewal of CSC or breast cancer stem-like cells	PKCζ/MAPK	TNBC	–	(66)
JAK	Up	Promote colon cancer tolerance to chemotherapy drugs	APC	colon cancer	–	(69)
PTPN	Down	Improve the sensitivity of tumor treatment	Induces resistance of CD8 + T cells to TGFβ inhibition	–	CD8 + T cells	(70)
ANT2	–	Promote tumor cell resistance to EGFR-TKI	–	NSCLC	–	(73)
IDO1	Up	Causes chemical and immune evasion	JAK1/STAT1 JAK1/STAT3	–	–	(75)
HIF1	Up	Promote tumor resistance to chemotherapy drugs	Promotes dissociation between glycolysis and the TCA cycle	–	–	(77)
PLA2	–	Restore cancer cells’ sensitivity to chemicals	PI3K-AKT-mTOR	–	–	(82)