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. 2020 Oct 7;12:570116. doi: 10.3389/fnagi.2020.570116

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Copyright © 2020 Jiang, Gao, Shen, Zhu, Wang, Feng, Huang, Shen and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glycyrrhizic acid ameliorated cognitive declines in middle-aged mice, improved cerebral blood flow. (A) The chemical structure of Glycyrrhizic acid (GA). (B) Escape latency of six consecutive daily tests. Statistical comparisons used the repeated measures ANOVA. (C) First latency to the platform in the probe trial. (D) Time spent in the target quadrant in the probe trial. (E) Crossing times of the target platform in the probe trial. (F) Images of CBF in C57BL/6. (G) Quantification of blood perfusion in C57BL/6. GA (5 mg/kg, once every other day); Data represent mean ± SEM (n = 8 per group). *P < 0.05, **P < 0.01, vs. Ctrl.