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. 2020 Oct 7;11:587235. doi: 10.3389/fmicb.2020.587235

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Copyright © 2020 Yamashita, Nagaoka, Kimura, Suzuki, Fukumoto, Hayasaka, Kaku, Morinaga, Yanagihara and Konno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Bacterial loads in the lungs of mice infected with the MRSA strains (HUYM, NU1643, and NU1516) at 1 × 10⁸ CFU/mouse for lethal infection. Bacterial counts were validated 4 h (●) and 16 h (◽) after infection. Bars represent mean bacterial counts, n = 6–8 mice/group. The broken horizontal line represents the lower limit of detection (1.7 log10 CFU/ml of lung specimen). Similar results were obtained from two independent experiments. Transcript levels of (B) rnaIII, (C) hla, (D) spa, (E) tst, and (F) pvl measured 4 h (●) and 16 h (◽) after inoculation in mice infected with MRSA strains (HUYM, NU1643, and NU1516). Bars represent the mean relative mRNA expression. Data are representative of 6–8 mice from two independent experiments. ^*p < 0.05; ^**p < 0.005; ^***p < 0.001; and n.s., not significant.