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Pathophysiological consequences of TMPRSS2—mediated ACE2 cleavage in SARS-CoV-2 infection. The TMPRSS2-mediated ACE2 cleavage promotes viral uptake through the cathepsin L-dependent pathway, inactivates the ACE2 membrane-bound form leaving the tissue unprotected against detrimental effect of RAS activation and does not release the soluble blocking form of ACE2.
