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. 2020 Oct 10;37:101749. doi: 10.1016/j.redox.2020.101749

Fig. 2.

Fig. 2

HFD stimulates adipocyte hypertrophy and mitochondrial dysfunction in CKO mice. (A) Body weight of WT and CKO mice fed ND or HFD for 4 weeks. (B) Body composition (%) of WT and CKO mice fed ND or HFD. (C) H&E staining of epididymal fat of WT and CKO mice fed ND or HFD ( × 100). (D) Plasma lipid profiles of WT and CKO mice fed ND or HFD. (E) H2O2 concentration in epididymal fat of WT and CKO mice fed ND or HFD. (F) Relative mRNA levels of NOX4 and p22phox in epididymal fat of WT and CKO mice fed ND or HFD. (G) Protein levels of PGC1α, TFAM, and NRF1 relative to GAPDH and pAMPKα (relative to AMPKα) in epididymal fat of WT and CKO mice fed ND or HFD. qPCR analysis of (H) FA oxidation- and (I) TCA cycle-related mRNA in epididymal fat of WT and CKO mice fed ND or HFD. Data are expressed as the mean ± SEM; Student's t-test, n = 8, *P < 0.05, **P < 0.01, ***P < 0.001 versus ND-fed WT mice; #P < 0.05, ##P < 0.01, ###P < 0.001 versus HFD-fed WT mice.