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. 2020 Oct 7;14:535549. doi: 10.3389/fncel.2020.535549

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Copyright © 2020 Kiernan, Ewald, Ouellette, Wang, Agbeh, Knutson, Roopra and Watters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxia changes microglial gene expression and upregulates metabolic- and cytokine receptor-related genes. (A) Volcano plot of microglial differential gene expression after Hx exposure. Red dots are upregulated genes, blue dots are downregulated genes. (B) Upregulated genes were analyzed for KEGG pathway enrichment using STRING software. The numbers at the end of each bar represent the observed/expected genes in each category. (C) FPKMs of genes upregulated by Hx that are in the categories of “cytokine-cytokine receptor interaction” or “HIF-1 signaling.” Results are derived from n = 3 biological replicates/treatment.