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. 2020 Sep;8(17):1064. doi: 10.21037/atm-20-2118

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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CRP alleviates Ang II-induced hypertrophy in cardiomyocytes. (A) Immunostaining of NRCMs for α-actinin indicated that CRP treatment of NRCMs attenuated the Ang II-stimulated increase in cardiomyocyte size, scale bars =50 µm (n=6); (B) qRT-PCR results showed that CRP-treatment significantly prevented the Ang II-induced hypertrophic marker (Anp and Bnp) expression in NRCMs (n=6). Data are presented as mean ± SD. *, P<0.05; **, P<0.01. CRP, Citri reticulatae Pericarpium; Ang II, angiotensin II; NRCMs, neonatal rat cardiomyocytes; Anp, natriuretic peptide type A; Bnp, natriuretic peptide B.