Table 3. Subgroup analyses of optimal cutoff value in different population sets of Chinese cohort.
| Population | No. of patients (%) | 3-year OS (%) | 5-year OS (%) | HR (95% CI) | P value |
|---|---|---|---|---|---|
| Female | 0.054 | ||||
| ELNs >31 | 5 (27.8) | 80.0 | 60.0 | 1 (Ref.) | |
| ELNs ≤31 | 13 (72.2) | 22.6 | 0 | 8.255 (0.868–70.375) | |
| Male | 0.001 | ||||
| ELNs >31 | 24 (36.4) | 62.5 | 45.8 | 1 (Ref.) | |
| ELNs ≤31 | 42 (63.6) | 28.6 | 7.1 | 3.020 (1.593–5.723) | |
| Age ≤60 years | 0.001 | ||||
| ELNs >31 | 15 (37.5) | 80.0 | 60.0 | 1 (Ref.) | |
| ELNs ≤31 | 25 (62.5) | 32.0 | 8.0 | 4.616 (1.843–11.557) | |
| Age >60 years | 0.002 | ||||
| ELNs >31 | 14 (31.8) | 57.1 | 42.9 | 1 (Ref.) | |
| ELNs ≤31 | 30 (68.2) | 13.3 | 3.3 | 3.653 (1.593–8.378) | |
| Tumor ≤4 cm | <0.001 | ||||
| ELNs >31 | 9 (47.4) | 88.9 | 77.8 | 1 (Ref.) | |
| ELNs ≤31 | 10 (52.6) | 30.0 | 10.0 | 10.849 (2.209–53.275) | |
| Tumor >4 cm | 0.001 | ||||
| ELNs >31 | 20 (30.8) | 55.0 | 35.0 | 1 (Ref.) | |
| ELNs ≤31 | 45 (69.2) | 20.9 | 4.4 | 2.795 (1.480–5.275) | |
| Upper third | 0.036 | ||||
| ELNs >31 | 5 (19.2) | 80.0 | 60.0 | 1 (Ref.) | |
| ELNs ≤31 | 21 (80.8) | 28.6 | 14.3 | 9.966 (2.185–45.449) | |
| Middle third | |||||
| ELNs >31 | 9 (56.2) | 33.3 | 33.3 | 1 (Ref.) | |
| ELNs ≤31 | 7 (43.8) | 28.6 | 0 | 2.273 (0.751–6.880) | 0.130 |
| Lower third | <0.001 | ||||
| ELNs >31 | 12 (41.4) | 83.3 | 50.0 | 1 (Ref.) | |
| ELNs ≤31 | 17 (58.6) | 17.6 | 5.9 | 5.571 (2.005–15.484) | |
| >2/3 stomach | 0.395 | ||||
| ELNs >31 | 3 (23.1) | 33.3 | 33.3 | 1 (Ref.) | |
| ELNs ≤31 | 10 (76.9) | 30.0 | 10.0 | 1.867 (0.401–8.688) | |
| Intestinal | 0.005 | ||||
| ELNs >31 | 20 (46.5) | 65.0 | 50.0 | 1 (Ref.) | |
| ELNs ≤31 | 23 (53.5) | 26.1 | 13.0 | 2.784(1.786–5.998) | |
| Diffuse | 0.003 | ||||
| ELNs >31 | 9 (17.9) | 66.7 | 44.4 | 1 (Ref.) | |
| ELNs ≤31 | 32 (82.1) | 21.9 | 3.1 | 3.952 (1.489–10.491) | |
| TG | 0.013 | ||||
| ELNs >31 | 12 (36.4) | 62.9 | 62.9 | 1 (Ref.) | |
| ELNs ≤31 | 21 (63.6) | 16.3 | 16.3 | 3.376 (1.210–11.537) | |
| PG | 0.235 | ||||
| ELNs >31 | 5 (31.2) | 80.0 | 60.0 | 1 (Ref.) | |
| ELNs ≤31 | 11 (68.8) | 58.4 | 29.2 | 2.578 (0.511–13.015) | |
| DG | <0.001 | ||||
| ELNs >31 | 12 (34.3) | 83.3 | 58.3 | 1 (Ref.) | |
| ELNs ≤31 | 23 (65.7) | 30.4 | 4.3 | 5.597 (2.035–15.396) |
No., number; OS, overall survival; HR, hazard ratio; 95% CI, 95% confidence interval; ELNs, examined lymph nodes; Ref, reference; TG; total gastrectomy; PG, proximal gastrectomy; DG, distal gastrectomy.