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. 2020 Sep;8(17):1050. doi: 10.21037/atm-20-922

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Associations of tumor mutation burden (TMB) and tumor aneuploidy levels (TALs) with CD8+ T cell enrichment levels, immune cytolytic activity (ICA), and PD-L1 expression levels. (A) TMB has a significant positive correlation with PD-L1 expression levels in TCGA-GC cohort (Student’s t test, P=0.03). (B) TALs have a significant negative correlation with CD8+ T cell enrichment levels, immune cytolytic activity, and PD-L1 expression levels in both TCGA- and ACRG-GC cohorts (Student’s t test, P<0.001). For each tumor sample, its TMB is the total somatic mutation count and TAL is the tumor ploidy score calculated by ABSOLUTE (29). ***, P<0.001.