FIGURE 3.

Transmission electron microscopy highlighting the appearance of junctions between TY10 endothelial cells within the brain microvessel-on-a-chip. The upper left panel shows a schematic cross section of the brain microvessel-on-a-chip highlighting the location of the monolayer of TY10 endothelial cells at the interface between the lumen of the microvessel and the collagen. The representative images in the bottom panels derive from junctions between opposite ends of adjacent cells. The yellow arrows highlight electron-density characteristic of tight junctions. Scale bars with corresponding magnifications are indicated.