Table 2. The univariate analysis of the factors associated with esophageal fistula.
| Variables | OR | 95% CI | P value |
|---|---|---|---|
| Age | |||
| ≤60 | 1.0 | ||
| >60 | 0.704 | 0.369–1.44 | 0.285 |
| Gender | |||
| Male | 1.0 | ||
| Female | 0.593 | 0.224–1.569 | 0.288 |
| KPS | |||
| ≤80 | 1.0 | ||
| >80 | 1.765 | 0.818–3.811 | 0.144 |
| History of smoking | |||
| No | 1.0 | ||
| Yes | 1.554 | 0.756–3.196 | 0.228 |
| Diabetes | |||
| No | 1.0 | ||
| Yes | 1.342 | 0.491–3.666 | 0.767 |
| Esophageal stenosis | |||
| No | 1.0 | ||
| Yes | 2.424 | 1.235–4.758 | 0.008 |
| Tumor location | |||
| Cervical/upper | 1.0 (reference) | ||
| Middle | 1.437 | 0.688–3.002 | 0.333 |
| Lower | 0.815 | 0.334–1.989 | 0.653 |
| Ulcerative tumor | |||
| No | 1.0 | ||
| Yes | 3.463 | 3.334–3.608 | <0.001 |
| T stage | |||
| T1–3 | 1.0 | ||
| T4 | 1.614 | 0.770–3.384 | 0.202 |
| N stage | |||
| N0–1 | 1.0 | ||
| N2–3 | 1.076 | 0.429–2.698 | 0.876 |
| Total dose (Gy) | |||
| ≥60 | 1.0 (reference) | ||
| ≥50 <60 | 0.942 | 0.410–2.163 | 0.887 |
| <50 | 2.217 | 0.926–5.311 | 0.074 |
| NLR | |||
| ≤2.44 | 1.0 | ||
| >2.44 | 2.695 | 1.358–5.347 | 0.004 |
| PLR | |||
| ≤153 | 1.0 | ||
| >153 | 3.100 | 1.615–5.952 | <0.001 |
| MLR | |||
| ≤0.30 | 1.0 | ||
| >0.30 | 3.360 | 1.727–6.538 | <0.001 |
OR, odds ratio; CI, confidence interval; KPS, Karnofsky performance status; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio.