Table 2.
Top pathways for differentially expressed genes in CS (with labor) vs. vaginal delivery.
| Pathway | Adjusted p-value | Group with upregulation | Genes |
|---|---|---|---|
| Antimicrobial peptides | 0.008 | VD | GNLY;DEFA4;SEMG1;DEFA3;PRTN3;CTSG; DEFA1;DEFA1B;PI3;ELANE;GZMH |
| Interferon alpha/beta signaling | 0.008 | VD | RSAD2;OAS3;MX1;IFIT1;USP18;OASL |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | 0.009 | VD | TRAV19;CD40LG;IGLV7-46;IGKV1-12; MADCAM1;KIR3DL2;IGLV7-43;SIGLEC1; SIGLEC8;KLRG1 |
| Chemokine receptors bind chemokines | 0.009 | VD | CCL5;CXCR3;XCL2;CCR9;CXCR6 |
| Interferon Signaling | 0.01 | VD | HERC5;RSAD2;OAS3;MX1;IFIT1; USP18; HLA-DQB2;OASL |
| Antiviral mechanism by IFN-stimulated genes | 0.01 | VD | HERC5;OAS3;MX1;IFIT1;USP18;OASL |
| Neutrophil degranulation | 1.66 × 10–9 | CS with labor | SERPINB10;MGST1;HP;SLC2A3;GPR84;RETN; LILRA3;FCAR;PLAC8;TRPM2;HK3;GM2A; ALOX5;CLEC5A;STOM;S100A12;CD59;CD36; GYG1;CD55;CD177;MGAM;SERPINB1;FCER1G; CR1;SERPINB2;GCA;ARG1;GPR97;C19orf59; ATP11B;MMP8;OLFM4;MAPK14;MMP9;CKAP4;CEACAM1;CLEC4D;VNN1;DLC1;SLCO4C1; S100P;CYSTM1;S100A9;CD44;S100A8 |
| Interleukin-4 and Interleukin-13 signaling | 0.004 | CS with labor | SOCS3;ANXA1;BCL6;HGF;ALOX5;OSM;RHOU; CD36;JAK2;MMP9 |
All pathways containing at least 5 differentially expressed genes and with an adjusted p-value ≤ 0.05 are included in the table. Out of a total of 506 differentially expressed genes, 163 and 343 genes were upregulated in VD and CS with labor respectively.
VD vaginal delivery; CS Cesarean section delivery.