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. 2020 Oct 20;11:5287. doi: 10.1038/s41467-020-19109-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a View from within the plane of membrane. GnRH1R is shown in sky blue cartoon representation. The N terminus is displayed as sand cartoon. The antagonist elagolix is shown as sphere with cyan carbons. b View from the extracellular side of the membrane. Left one represents sky blue cartoon receptor with cyan sphere ligand. Right one shows the surface representation of 7-TM domain, key residues of the N terminus that are shown in sand sticks inserted the orthosteric pocket. The N terminus is displayed as sand cartoon. c View from the intracellular side of the membrane, structural comparison of GnRH1R (sky blue) with G protein -bound active NTS1R (6OS9, orange). d |Fo| − |Fc| omit map (contoured at 3.0σ) of the ligand elagolix. The antagonist elagolix is shown as cyan sticks.