FIGURE 1.

Dihydrotanshinone I selectively attenuates proliferation of SOC cells but not normal ovarian epithelial cells. A, IC50 of four compounds of the tanshinone family in human ovarian cancer cell line A2780. Ovarian cancer cells were treated with various concentrations of DHTS, tanshinone IIA, tanshinone I and cryptotanshinone for 48 h. Then, cell viability was determined by MTT assay. B, Anti‐proliferative effect of DHTS in IOSE80, A2780 and OV2008 cells by MTT assay. Cell lines were treated with various concentrations of DHTS (0, 1, 2, 4, 6, 8 and 10 μM) for 24 h or 48 h. Data represent means ± SEM of triplicate samples. *P < .05 and **P < .01 vs. untreated control