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. 2020 Aug 27;19(10):e13220. doi: 10.1111/acel.13220

Figure 2.

Figure 2

Morris water maze performance in young and aged animals treated with control or IRβ AAVs. (a) Path length to goal across learning (training days) and memory (probe day). All animals (young control n = 8, young IRβ n = 5, aged control n = 5, aged IRβ n = 6) learned the task successfully, as indicated by reductions in path length across the training days (3‐way RM ANOVA; F (1.82,36.41) = 22.67, p < 0.001). As expected, aged animals learned at a slower rate than young animals (3‐way RM ANOVA; F (1,20) = 7.97, p = 0.012). Asterisk (*) indicates significant main effect of training at p < 0.05. Ampersand (&) indicates significant main effect of age at p < 0.05. (b) Analysis of memory (24 h) on the probe task revealed both a significant aging effect (2‐way ANOVA; F (1,20) = 6.92, p = 0.016) and interaction term (2‐way ANOVA; F (1,20) = 5.82, p = 0.026) whereby aged animals treated with IRβ showed reductions in path length to proximity ring. Asterisks (*) indicate significance at p < 0.05. All data represent means ± SEM