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. 2020 Sep 2;24(19):11056–11063. doi: 10.1111/jcmm.15743

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© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ubiquitination mediated regulation of Treg immunosuppression. E3 ligase Stub1 regulates Foxp3 stability through K48‐linked ubiquitination, and E3 ligase TRAF6 regulates Foxp3 localization and localization through K63‐linked ubiquitination. Deubiquitinase Usp11 enhances Foxp3 expression through TGF‐β/Smad signalling. E3 ligase Hrd1 maintains the suppressive function of Tregs through up‐regulating the secretion of IL‐10, activating MAPK/p38 signalling and enhancing the expression of Foxp3