FIGURE 6.

RAGE/PPARα pathway in hepatic steatosis patients. (a–d) H&E‐stained liver sections (a), hepatic TG levels (b), expression levels of RAGE, PPARα, CPT1a, CPT1b, and MCAD (c) and copy numbers of MT‐CYB and 12S rRNA (d) of NAFLD patients separated into two groups. (e) Schematic model: We propose that aging induces RAGE upregulation, which inhibits PPARα signaling and suppresses mitochondria‐related fatty acid β‐oxidation, eventually leading to excessive FFA production and then hepatic steatosis