Figure 7.

Exosomal ADAMTS9‐AS1 may serve as a diagnostic marker for CRC. A, Representative TEM images of serum exosomes, scale bar, 100 nm. B, Western blot analysis of TSG101 and CD9 in exosomes and exosome‐depleted supernatants (EDS). C, NTA of the size distribution and number of exosomes. D, RNA expression of exosomal ADAMTS9‐AS1 was measured in the serum of healthy controls (n = 130) and the serum of CRC patients (n = 130) using qPCR. E, F, ROC curve for serum exosomal ADAMTS9‐AS1 for the discrimination of patients with CRC from normal healthy individuals both in training set and in validation set. **P < .01, ***P < .001, ****P < .0001