FIGURE 1.

circVMA21 alleviated the symptoms of CLP‐induced sepsis‐associated AKI rat model. (A) Relative expression level of circVMA21 in sepsis‐associated AKI patients and LPS‐treated HK‐2 cells. (B) Relative expression level of circVMA21 in CLP‐induced AKI rats. (C) Blood urea nitrogen (BUN) and (D) serum creatinine (sCr) levels in rat blood samples. (E) Urine neutrophil gelatinase‐associated lipocalin (uNGAL) and (F) urine kidney injury molecule‐1 (uKIM‐1) levels in rat urine samples. (G) Pathological morphology HE (haematoxylin‐eosin) staining of the renal tissue. (H) Semi‐quantitative histopathological score of renal tissue on a scale of 0‐5 based on images with a magnification of 400. *P < 0.05, ***P < 0.001. Data were presented as mean ± SD from four independent experiments. Sham: the rat caecum was exposed without perforation; CLP: caecal ligation and puncture (CLP) surgery for Wistar rats