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. 2020 Sep 11;24(19):11489–11499. doi: 10.1111/jcmm.15763

FIGURE 3.

FIGURE 3

TLR4 participates in the damage of cartilage and subchondral bone in discectomy‐induced TMJOA mice. A, The arrangement of control cartilage was regular, and its matrix was abundant, in contrast, obvious disorder occurred in the cartilage of discectomy groups, while appeared mitigated after twice a week of TAK‐242 injections. B, The percentage of proteoglycan gradually decreased in the discectomy groups compared with control, whereas TAK‐242 injections significantly ameliorate the reducing of cartilage proteoglycans induced by discectomy alone (*: discectomy groups vs control; #: discectomy + TAK groups vs discectomy groups). C, Larger bone lesion of condyle (red arrows) and obvious atypical condyle shape were found in the micro‐CT image of discectomy groups, while these phenomena were ameliorated after twice a week of TAK‐242 injections. D‐G, The remodelling of subchondral bone was assessed by histomorphometric parameters, including ratio of bone volume to tissue volume (BV/TV), trabecular thickness (Tb. Th), trabecular number (Tb. N) and trabecular space (Tb. Sp). (Data were analysed by Student's t test, n = 3‐6, *P < .05, ***P < .001; #P < .05, ##P < .01, ###P < .001). (CON represents control; Discectomy + TAK represents discectomy combined with TAK‐242 injection groups)