FIGURE 5.

TLR4 promotes the expression of cartilage pro‐inflammatory and catabolic mediators in discectomy‐induced TMJOA mice. A, The expression of IL‐1β, TNF‐α, ADAMTS5 and MMP13 was detected by immunohistochemistry in the cartilage of discectomy groups, discectomy with TAK‐242 treatment groups at week 6, or in the control cartilage. B, The rate of IL‐1β, TNF‐α, ADAMTS5 or MMP13 positive cells in the cartilage was markedly increased in the discectomy groups, while markedly inhibited after treatment with TAK‐242. (Data were analysed by Student's t test, n = 6, **P < .01, ***P < .001). (CON represents control; Discectomy + TAK represents discectomy combined with TAK‐242 injection groups)