Table 2.
Associations of NLR with clinically relevant depressive symptoms among adults in NHANES (2009–2016).
| NLR | Unadjusted | Multivariable-adjusteda | Multivariable-adjustedb | Multivariable-adjustedc |
|---|---|---|---|---|
| OR (95% CIs) | OR (95% CIs) | OR (95% CIs) | OR (95% CIs) | |
| Tertile | ||||
| <1.75 | Ref. | Ref. | Ref. | Ref. |
| 1.75-2.57 | 1.24 (0.90, 1.70) | 1.20 (0.90, 1.60) | 1.16 (0.86, 1.58) | 1.08 (0.82, 1.43) |
| >2.57 | 1.68 (1.23, 2.30) | 1.78 (1.34, 2.35) | 1.74 (1.31, 2.32) | 1.57 (1.13, 1.87) |
| P for trend | 0.0009 | <0.0001 | 0.0023 | 0.0078 |
| Quartiles | ||||
| <1.56 | Ref. | Ref. | Ref. | Ref. |
| 1.56-2.13 | 1.08 (0.77, 1.51) | 1.07 (0.74, 1.55) | 1.07 (0.76, 1.50) | 1.25 (0.85, 1.83) |
| 2.13-2.86 | 1.41 (1.02, 1.96) | 1.44 (1.01, 2.05) | 1.40 (0.99, 1.95) | 1.46 (0.99, 2.14) |
| >2.86 | 1.85 (1.34, 2.56) | 1.71 (1.19, 2.46) | 1.79 (1.29, 2.50) | 1.62 (1.10, 2.39) |
| P for trendd | <0.0001 | 0.0010 | 0.0001 | 0.0134 |
Abbreviation: NLR: neutrophil-to-lymphocyte ratio; NHANES: National Health and Nutrition Examination Survey; Ref.: reference; OR: odds ratio; CI: confidence interval. aAdjusted for age, sex, and race. bAdjusted for age, sex, race, education, household annual income, smoking status, alcohol consumption, and BMI (normal weight, overweight, obese). cAdjusted for all covariables in b plus adjusted for HbA1c in quartiles, chronic conditions including HF, stroke, DR and CHD, glucose-lowering drugs, and insulin use.