Table 1.
Metabolic changes from first to last OGTT in progressors versus nonprogressors
| N | First OGTT, median (IQR) | Last OGTT, median (IQR) | Signed rank P value | P values (adjusted by change in age and BMI z score) | |
|---|---|---|---|---|---|
| Early C-peptide | |||||
| Progressor | |||||
| BiP to MoP | 43 | 3.37 (2.39) | 2.38 (1.83) | <0.001 | <0.001 |
| MoP to MoT | 5 | 2.20 (2.81) | 1.10 (0.69) | 0.138 | 0.480 |
| MoP to BiP | 30 | 2.22 (1.83) | 2.42 (2.14) | 0.192 | 0.137 |
| MoP to MoP | 204 | 2.33 (1.72) | 1.80 (1.44) | <0.001 | <0.001 |
| Nonprogressor | |||||
| BiP to MoP | 490 | 3.95 (2.77) | 3.88 (2.99) | 0.077 | 0.033 |
| MoP to MoT | 16 | 3.46 (3.93) | 1.83 (2.82) | 0.079 | 0.111 |
| MoP to BiP | 377 | 3.53 (2.85) | 3.97 (2.93) | 0.005 | 0.001 |
| MoP to MoP | 838 | 3.35 (2.67) | 3.27 (2.85) | 0.992 | 0.691 |
| C-peptide index | |||||
| Progressor | |||||
| BiP to MoP | 43 | 0.06 (0.05) | 0.03 (0.03) | <0.001 | <0.001 |
| MoP to MoT | 5 | 0.04 (0.03) | 0.02 (0.05) | 0.893 | 0.413 |
| MoP to BiP | 30 | 0.04 (0.04) | 0.03 (0.03) | 0.530 | 0.468 |
| MoP to MoP | 204 | 0.04 (0.02) | 0.03 (0.02) | <0.001 | <0.001 |
| Nonprogressor | |||||
| BiP to MoP | 490 | 0.078 (0.064) | 0.072 (0.057) | <0.001 | <0.001 |
| MoP to MoT | 15 | 0.076 (0.090) | 0.052 (0.075) | 0.017 | 0.029 |
| MoP to BiP | 377 | 0.065 (0.052) | 0.078 (0.068) | <0.001 | <0.001 |
| MoP to MoP | 837 | 0.058 (0.047) | 0.057 (0.051) | 0.974 | 0.517 |
| Index60 | |||||
| Progressor | |||||
| BiP to MoP | 43 | 0.23 (1.29) | 1.25 (1.33) | <0.001 | <0.001 |
| MoP to MoT | 5 | 1.30 (0.89) | 1.66 (1.18) | 0.893 | 0.625 |
| MoP to BiP | 30 | 1.18 (1.04) | 1.14 (0.73) | 0.614 | 0.886 |
| MoP to MoP | 204 | 1.10 (1.27) | 1.68 (0.88) | <0.001 | <0.001 |
| Nonprogressor | |||||
| BiP to MoP | 490 | −0.223 (1.264) | −0.329 (1.646) | 0.922 | 0.933 |
| MoP to MoT | 16 | −0.241 (2.795) | 0.818 (2.460) | 0.004 | 0.022 |
| MoP to BiP | 377 | −0.070 (1.555) | −0.282 (1.437) | <0.001 | <0.001 |
| MoP to MoP | 838 | 0.099 (1.523) | 0.094 (1.727) | 0.175 | 0.400 |
| AUC ratio | |||||
| Progressor | |||||
| BiP to MoP | 43 | 0.04 (0.02) | 0.03 (0.02) | <0.001 | <0.001 |
| MoP to MoT | 5 | 0.03 (0.02) | 0.02 (0.00) | 0.893 | 0.902 |
| MoP to BiP | 30 | 0.03 (0.02) | 0.03 (0.02) | 0.558 | 0.847 |
| MoP to MoP | 204 | 0.03 (0.02) | 0.02 (0.01) | <0.001 | <0.001 |
| Nonprogressor | |||||
| BiP to MoP | 490 | 0.045 (0.026) | 0.049 (0.029) | <0.001 | <0.001 |
| MoP to MoT | 16 | 0.053 (0.050) | 0.035 (0.042) | 0.003 | 0.012 |
| MoP to BiP | 377 | 0.044 (0.028) | 0.048 (0.027) | 0.001 | <0.001 |
| MoP to MoP | 838 | 0.044 (0.025) | 0.045 (0.028) | 0.002 | <0.001 |
BiP, biphasic; MoP, monophasic; MoT, monotonic.