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. 2020 Oct 6;4(10):e22485. doi: 10.2196/22485

Table 1.

Application of the Assessment, Decision, Adaptation, Production, Topical experts—Integration, Training, Testing framework with a preventive maintenance intervention texting adaptation in Afiya.

Phase Methodology decisions Results or observations
1. Assessment
  • Formed advisory board

  • Conducted an initial meeting with advisory board

  • Conducted meetings with intervention experts for the target population

  • The target population (African American adolescent females) requires interventions addressing their specific situation

  • The intervention needs to address safer sex norms, sexual negotiation, and refusal skills, HIV and STIa preventive attitudes

  • The advisory board was selected for project, met, and provided input on the plan

  • Advisory board members were paid as consultants to develop or test the feasibility of texting PMIb

2. Decision
  • Selected HORIZONS and Afiya interventions

  • Decided to adapt Afiya phone-based PMIs to texting PMIs

  • Original developer of Afiya-led adaptation

  • mHealthc and texting literature reviewed

  • HORIZONS, an evidence-based intervention that successfully reduced STIs and increased condom use among young women, was selected as it appropriately addressed the target population

  • Afiya selected as it demonstrated a PMI based on HORIZONS to the same target population, but extend the efficacy of the HORIZONS intervention

  • Texting is most likely the simplest mHealth adaptation to adapt from Afiya and appropriate implementation technology choice for the target population

3. Administration
  • Decided not to modify Afiya core elements

  • Decided to focus on Afiya core element support by texts

  • Adaptation would involve scripts and texts responses based on Afiya documents and data

  • Retention of primary intervention form assured standard of care and served as a shared primary intervention control (therefore, theater testing was not conducted)

  • 5 core elements of Afiya were identified to be supported by PMIs

4. Production
  • Designed 8-week iterative formative pilot plan for adaptation

  • Designed questionnaires and focus group–led questions

  • Designed initial texts and support scripts

  • Selected company for formative pilot texting

  • Reviewed with Afiya and HORIZONS creators

  • Reviewed plan with advisory board

  • Assembled Afiya workshop materials

  • Iterative formative pilot designed for advisory board

  • Primary intervention led by Afiya and HORIZONS developers in formative pilot and support scripts and associated text messages were created

  • Important to have both advisory board and intervention developers review pilot design and timing

  • Important to have intervention developers review PMI scripts and texting form or content (Draft 1 completed)

  • Texting platforms vary in terms of capacity, functionality, and cost. Total program costs should be estimated

5. Topical experts
  • Obtained review advice regarding HIPAAd issues relevant to texting

  • Obtained review advice regarding pre- and postintervention CASIe instruments for future effectiveness pilot

  • Met with texting companies (with advice from ITf) for future effectiveness pilot

  • CASI content should be reviewed for duplication or replication as well as total time required (test run the instrument)

  • Texting is not encrypted, so both HIPAA (and local IRBg/state) requirements must be reviewed regarding texted data and data privacy issues

  • Role, functionality, and cost of texting companies were more clearly defined with this experience

  • Overall costs for the 8-week formative pilot were made

6. Integration
  • Integrated Draft 1 and topical expert comments for scripts, SMS texting content or form (Draft 2)

  • Conducted Afiya workshop with advisory board

  • Integrated topical expert comments of pre- and postworkshop CASI materials

  • Integrated Draft 2 and CASI components (Draft 3)

  • Final review by advisory board and Afiya and HORIZONS creators

  • Draft 2 completed

  • Draft 3 completed

  • Final formative pilot design completed

7. Training
  • Created training materials for the formative pilot

  • Formative pilot materials completed

8. Testing
  • Submitted to IRB for clearance of the formative pilot


  • Obtained IRB clearance to determine adaptation efficacy



Step 1: formative pilot


  • Conducted 8-week formative pilot with advisory board: primary Afiya intervention, 4-week texting, focus group 1 (adjustments), 4-week texting, focus group 2 (adjustments)

  • Iterative pilot design provided important feedback on texts (timing, wording, dose) as well as script and CASI modifications

  • Information gathered during the first advisory board focus group was applied to modifying the second 4-week texting session, information gathered during the second 4-week focus group was also useful (topic experts were consulted during these sessions as necessary)

  • 5 personas identified, exit interviews added

  • Results informed design of adaptation impact pilot


Step 2: feasibility pilot


  • Designed texting PMI RCTh feasibility pilot study

  • Study methods submitted to IRB for approval

  • Obtained IRB clearance for 3-arm feasibility pilot study

  • Preparing for PMI RCT feasibility pilot study to examine short-term intervention efficacy

aSTI: sexually transmitted infection.

bPMI: preventive maintenance intervention.

cmHealth: mobile health.

dHIPAA: Health Insurance Portability and Accountability Act.

eCASI: computer-assisted self-interview.

fIT: information technology.

gIRB: Institutional Review Board.

hRCT: randomized controlled trial.