C-Score is an ideal predictor for adjuvant therapy efficacy in LAGC.
A. In LAGC patients with low C-Score, adjuvant chemotherapy demonstrated poor efficacy in prolong OS (log-rank p = 0.81 and 0.11 in SRRSH and TCGA cohort, respectively). B. In LAGC patients with medium chemo-score, adjuvant chemotherapy showed significant improved OS compare to surgery only patients (log-rank p = 0.03 and 0.01 in SRRSH and TCGA cohort, respectively). C. In LAGC patients with high C-Score, adjuvant chemotherapy showed significant improved OS compare to surgery only patients (log-rank p = 0.002 and 0.007 in SRRSH and TCGA cohort, respectively).