Fig. 4.

The C-Score is associated with mutation type and burden in LAGC.

A. The waterfall plots of mutation profiles of LAGCs from TCGA were depicted, the patients with low C-Score demonstrated a significantly higher rate of functional mutations than group median and high group. B. The waterfall plots of mutation profiles of 28 gastric cancer cell lines. Cell lines with low chemo-signature (group low) showed high frequency of frameshift mutations in and high frequency of missense mutation than group median and group high cell lines.