Table 2.
Univariable and multi-variable Cox proportional hazard analysis in SRRSH cohort.
| Gene signatures | Treatment | Univariable model |
Multi-variable model |
||
|---|---|---|---|---|---|
| HR (95% CI) | Pa | HRb (95% CI) | Pa | ||
| RRM1 | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.74 (0.45–1.23) | 0.25 | 0.72 (0.42–1.23) | 0.23 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.52 (0.33–0.84) | 0.007 | 0.66 (0.40–1.10) | 0.11 | |
| RRM2B | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.57 (0.35–0.97) | 0.04 | 0.55 (0.31–0.99) | 0.045 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.70 (0.45–1.09) | 0.12 | 0.85 (0.72–1.92) | 0.51 | |
| RRM2 | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.51 (0.30–0.84) | 0.008 | 0.54 (0.32–0.89) | 0.02 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.78 (0.49–1.24) | 0.3 | 0.97 (0.57–1.66) | 0.92 | |
| POLH | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.34 (0.19–0.60) | 0.0003 | 0.37 (0.20–0.68) | 0.001 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.92 (0.60–1.42) | 0.71 | 1.05 (0.66–1.67) | 0.84 | |
| dUTPase (DUT) | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.63 (0.35–1.11) | 0.11 | 0.63 (0.35–1.31) | 0.13 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.65 (0.43–1.00) | 0.05 | 0.82 (0.51–1.31) | 0.41 | |
| Ki67 | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.52 (0.29–0.92) | 0.02 | 0.49 (0.25–0.95) | 0.034 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.74 (0.48–1.13) | 0.17 | 0.85 (0.55–1.33) | 0.48 | |
| TYMS | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.55 (0.31–1.01) | 0.05 | 0.60 (0.37–1.14) | 0.12 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.78 (0.52–1.18) | 0.25 | 0.90 (0.57–1.42) | 0.65 | |
| TYMP | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.60 (0.40–0.89) | 0.01 | 0.67 (0.44–1.03) | 0.07 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.84 (0.45–1.57) | 0.6 | 0.97 (0.47–1.97) | 0.92 | |
| Chemo-signature | |||||
| Low | Surgery alone | Reference | Reference | ||
| Surgery + AC | 1.37 (0.65–2.97) | 0.41 | 2.11 (0.84–5.56) | 0.11 | |
| Medium | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.61 (0.37–1.00) | 0.05 | 0.64 (0.38–1.10) | 0.1 | |
| High | Surgery alone | Reference | Reference | ||
| Surgery + AC | 0.39 (0.21–0.72) | 0.003 | 0.44 (0.23–0.83) | 0.01 | |
AC: adjuvant chemotherapy.
a
Indicate p-value <0.05.
b
Adjusted by age and sex.