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. 2020 Aug 25;69(11):2446–2457. doi: 10.2337/db20-0579

Figure 3.

Figure 3

Blocking YAP-TEAD association reduced interstitial fibrosis in diabetic mouse kidneys. Nine- to 10-week old STZ diabetic eNOS−/− mice (A and B) or unilateral nephrectomized diabetic FVB/NJ mice (C and D) were administered vehicle or verteporfin (Vert) (100 mg/kg i.p. every other day) for 20 weeks: immunoblotting analysis of CTGF expression in renal cortical tissue lysates (A and C), representative immunohistochemical (IHC) staining of collagen I expression in both interstitial area and glomeruli (original magnification ×400) (B), and representative histology data of Sirius Red staining (original magnification ×200) (D). Values are mean ± SEM (n = 5–10 for each group). Veh, vehicle. *P < 0.05, ***P < 0.001.