Figure 4.

Proximal membrane, transmembrane, and intracytoplasmic amino acid sequences of select HLA-DQA-DQB alleles, showing the positions of linked residues associated with resistance to T1D. The two intramembrane sequences have been aligned in nearly identical topographical positions, despite different numberings of the sequences, for ease of comparison. For complete listing of associated alleles, see Table 1. The alleles are color coded in order to show which HLA-DQA molecules can pair with their structural matches from HLA-DQB molecules (purple color with purple color and olive green color with olive green color). The gray-shaded sequence concerns the intramembranous stretch.