Table 3.

Motif association results with selected residues from both α-chain and β-chain (αa1,α157,α196, β9, β30, β57, and β70) with at least five copies of haplotypes

Estimated haplotype frequencies (percentages) (excluding those motifs with fewer than 3 copies) among control subjects, those among patients, estimated ORs, z scores, and P values (from association analysis with T1D in case-control study) are listed. For given haplotypes, one or more DQA1-DQB1 haplotypes may be merged into haplotype groups. Motif association results for individual DQ clusters are listed in Supplementary Table 3. The haplotype (DQ6.2) is highlighted in red, to indicate that its motif (also highlighted in red, “DAAFYDG”) is treated as the reference. For other motifs, the same amino acids to those in the reference motif are denoted by “.”