Table 2.
CPT1A association result.
| FA level | Main SNP effect | SNP × traditional diet | ||
|---|---|---|---|---|
| SNP beta (SE) | p value | SNP × diet beta (SE) | GC p value | |
| 18:1 omega-9 | −3.84E − 01 (4.37E − 02) | 6.06E − 18 | 2.10E − 03 (1.89E − 03) | 2.94E − 01 |
| 20:1 omega-9 | −4.52E − 01 (3.68E − 02) | 1.88E − 32 | 4.02E − 03 (1.49E − 03) | 7.38E − 03 |
| 18:2 omega-6 | −3.68E − 01 (3.60E − 02) | 2.20E − 23 | 4.45E − 03 (1.53E − 03) | 1.18E − 02 |
| 20:3 omega-6 | −3.18E − 01 (3.71E − 02) | 3.12E − 17 | 5.67E − 03 (1.52E − 03) | 3.99E − 04 |
| 20:4 omega-6 | 3.07E − 01 (3.93E − 02) | 1.23E − 14 | −2.69E − 03 (1.66E − 03) | 1.00E − 01 |
| 22:4 omega-6 | 4.41E − 01 (3.66E − 02) | 1.94E − 31 | −9.39E − 04 (1.50E − 03) | 5.06E − 01 |
| 20:0 | −4.03E − 01 (4.19E − 02) | 5.03E − 21 | 5.08E − 03 (1.84E − 03) | 1.63E − 02 |
| 22:0 | −4.32E − 01 (3.88E − 02) | 3.08E − 27 | 2.94E − 03 (1.67E − 03) | 8.98E − 02 |
| 24:0 | 4.09E − 01 (3.97E − 02) | 1.02E − 23 | −4.73E − 03 (1.67E − 03) | 1.39E − 02 |
| 20:5 omega-3 | 8.68E − 02 (3.75E − 02) | 2.06E − 02 | 3.58E − 03 (1.47E − 03) | 7.42E − 02 |
| 22:5 omega-3 | 3.63E − 01 (4.23E − 02) | 3.47E − 17 | 8.06E − 03 (1.79E − 03) | 9.63E − 04 |
| 22:6 omega-3 | −4.22E − 02 (4.06E − 02) | 2.99E − 01 | 1.61E − 03 (1.78E − 03) | 4.91E − 01 |
Analysis of the main and interaction effect of the SNP on levels of each fatty acid. Analysis for the main SNP effect was adjusted for age, sex, and cell type measured (erythrocytes or all blood cells) as fixed effects and including the genetic similarity matrix as random effect. Analysis for the SNP × diet interaction effect was adjusted for age, sex, cell type measured (erythrocytes or all blood cells), SNP effect, and diet as fixed effects and including the genetic similarity matrix as random effect. SNP beta and SNP × diet beta is the estimated effect size in standard deviations. GC p value: p values after applying genomic control. Significant interaction effects are marked with bold (p < 0.00417).